Born in Havana, Cuba, Osmeivy Ortega graduated from the Nacional Academy of Fine Arts San Alejandro (2003) in the specialty of Engraving, The Royal Instiute of Art (Kungliga Konsthögskolan) Stockholm, Sweden (2009), and the Higher Institute of Art, ISA (2005).

He has been awarded many international artistic residences, including Documenta, Kassel, Germany. He is a member of the Union of artists and Writers of Cuba and of the Experimental Graphic Workshop of Havana, and a Professor in the Engraving Specialty from 2003 to 2015 at the San Alejandro Academy and ISA. He has had solo exhibitions in Cuba, New Zealand, and the United States and has participated in more than 100 group shows.

His works are in public collections belonging to the Cuban Fund of Cultural Assets; AMBA collection, Paris; Rockefeller Foundation, New York; and his work can be found in private collections in Cuba, Colombia, Mexico, Japan, Portugal, Turkey, the United States, Spain, and the United Kingdom.